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. 2004 May 18;4:6. doi: 10.1186/1471-2210-4-6

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Copyright © 2004 Garg and Chang; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

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Prevention of tBH-induced mitochondrial membrane depolarization by 15d-PGJ₂. Cells were pretreated with serum-free medium (control) or with 1 μM 15d-PGJ₂(prepared in serum-free medium) overnight, then with 400 μM, 500 μM or 600 μM tBH (without 15d-PGJ₂) for 4 hours. The 545/595 emission intensity ratio of each treatment was determined. Results indicated that tBH caused an increase of the 545/595 emission intensity ratio, which was completely prevented by 15d-PGJ₂pre-treatment. Preliminary results indicated that tBH treatment for 4 hours was required to see a significant increase of 545/595 emission intensity ratio (data not shown).