Table 3.
Association between CCT-associated SNPs and KC risk in the Saudi Arabian study population
| Locus | Lead SNP | A1/A2 | MA | MAF Case | MAF Control | p-value | OR (95 % CI) |
|---|---|---|---|---|---|---|---|
| COL4A3 | rs7606754 | A/G | A | 0.35 | 0.37 | 0.6 | 0.9 (0.7-1.3) |
| FNDC3B | rs4894535 | C/T | T | 0.16 | 0.12 | 0.1 | 1.4 (0.9-2,2) |
| MPDZ-NF1B | rs1324183 | A/C | A | 0.25 | 0.28 | 0.4 | 0.8 (0.8-1.2) |
| RXRA-COL5A1 | rs1536482 | A/G | A | 0.45 | 0.41 | 0.4 | 1.1 (0.8-1.6) |
| COL5A1 | rs7044529 | C/T | T | 0.14 | 0.13 | 0.8 | 1.1 (0.7-1.7) |
| LCN12-PTGDS | rs11145951 | C/T | T | 0.44 | 0.49 | 0.2 | 0.8 (0.6-1.1) |
| FOXO1 | rs2721051 | C/T | T | 0.14 | 0.11 | 0.2 | 1.4 (0.9-2.2) |
| BANP-ZNF49 | rs9938149 | A/C | C | 0.29 | 0.32 | 0.4 | 0.9 (0.6-1.2) |
CCT Central cornea thickness; SNP single nucleotide polymorphism; KC keratoconus; A1/A2 Allele 1/Allele 2; MA minor allele; MAF minor allele frequency; p-value, derived from two-tailed fisher exact test; OR odds ratio; CI confidence interval. COL4A3 Collagen, type IV, alpha (Goodpasture antigen); FNDC3B fibronectin type III domain containing 3B; MPDZ multiple PDZ domain protein; NF1B neurofibromin 1b; COL5A1 collagen, type V, alpha 1; LCN12 lipocalin 12; PTGDS prostaglandin D2 synthase 21 kDa; FOXO1 forkhead box O1; BANP BTG3 associated nuclear protein; ZNF469 zinc finger protein 469