Table 3.

Selected studies comparing local control as a function of BED

Author, year	Stage	Dose, BED10	Local control	P value
Van der Voort van Zyp et al. 2009 [19]	T1, n = 35; T2, n = 24	180 Gy	96 % at 2 years	n.s. p = 0.197
		112. 5 Gy	78 % at 2 years
Onimaru et al. 2008 [20]	T1, n = 25; T2, n = 16	80 Gy	45 at 2 years	p = 0.0042
		105.6 Gy	89 % at 2 years
Guckenberger et al. 2009 [21]	T1, n = 13; T2, n = 19; T3N0, n = 9	>100 Gy	89 % at 3 years	p = 0.0001
		<100 Gy	62 % at 3 years
Bibault et al. 2012 [6]	T1, n = 31; T2, n = 20	≤150 Gy	70 % at 2 years	p = 0.006
		>150 Gy	100 % at 2 years
Grills et al. 2012 [22]	T1, n = 318; T2, n = 67; T3, n = 10	<105 Gy	85 % at 2 years	p < 0.001
		>105 Gy	96 % at 2 years
Onishi et al. 2007 [23]	Stage I, n = 257	>100 Gy	84 % at 3 years	p <0.01
		<100 Gy	37 % at 3 years