Figure 3.
Small RNAs, such as miRNAs, have both cytoplasmic (PTGS) and nuclear functions. They can be secreted to extracellular space in microvesicles, low-density lipoprotein (LDL) particles or exosomes and can be internalized by recipient cells. Their functions in recipient cells are still unclear, but can include PTGS or TGS/TGA.