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. 2015 Jun 10;5:11252. doi: 10.1038/srep11252

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(a) The impairment of LTP induced by perfusion with SB431542 (thirty minutes before tetanus) is rescued by TGF-β1 (ten minutes before tetanus). (b) Western blot analyses shows that SB431542 treatment blocks the physiological phosphorylation of CREB expected after a strong tetanus, whereas TGF-β1 rescues p-CREB levels in SB431542-treated tetanized slices. (c) Western blot analyses shows that SB431542 treatment induces a decrease of phospho-SMAD2 (ser465/467) whose levels are partially rescued by TGF-β1. *significant difference (p < 0.05).