Table 3.
Relationship between plasma concentrations of GHB and state of consciousness after intravenous adminsitration. N = 16 patients received 50-115 mg/kg of GHB and afterwards the hypnotic effect was observed for 20-300 min post-dosing [72].
| Mean (Range) of GHB Concentration, mg/L | Clinical Observations/Hypnotic Effects1 |
|---|---|
| 311 (244-395) | Deep sleep (no response to stimuli) |
| 224 (151-293) | Medium sleep (blinking) |
| 135 (63-162) | Light sleep (occasioanl eye opening) |
| 47 (0-99) | Awake |
1The clinical effects lagged behind the peak plasma concentration.