Figure 5. Specific Nanoparticle Targeting of Tumour Tissue.

The delivery across fenestrations was accessed for normal fenestration sizes and larger fenestrations resembling vasculature of cancer tissue (A). Polydisperse (Pd) nanoparticle populations generated from DLS size data were used alongside monodisperse (Md) populations of the average sizes, fenestration sizes are indicated by dashed lines (B). The percentage uptake after 0.5 s is compared between normal fenestrations and tumour fenestrations (C). Polydisperse populations are compared to their sized matched monodisperse populations for uptake in fenestrations at 0.5 s; a dashed baseline is used in place of the normalised monodisperse populations but error bars are included used (D). A comparison was then made between the average size of the nanoparticles within fenestrations and those within the vessel for the polydisperse populations (E). Finally the relative volume of nanoparticle mass delivered across fenestrations was compared between polydisperse populations and their equivalent monodisperse population at 0.5 s; a dashed baseline is used in place of the normalised monodisperse populations but error bars are included used (F). * P < 0.01, ** P < 0.005, *** P < 0.001.