| Persistence/expansion | Autocrine cytokine production (IL-2, IL-15, and mbIL-15) |
| Migration | CCR7 and CXCR3 |
| Cytotoxicity | CARs, CD16, autocrine cytokine production (IL-2 and IL-15), and overexpression of double negative TGF-β II receptor to avoid suppressive effects of TGF-β. Silencing of inhibitory NK cell receptors, such as NKG2A |
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