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. Author manuscript; available in PMC: 2015 Jun 10.
Published in final edited form as: Brain Behav Immun. 2012 Mar 7;26(4):650–659. doi: 10.1016/j.bbi.2012.02.009

Table 6. Results of the multiple mediation analyses of the hypothesized mediating roles of IL-6, TNF-α, and CRP in the effects of Overall Stress (Model 1) and Pregnancy-Specific Distress (Model 2) on gestational age at birth early, late, and averaged across pregnancy. Significant mediating relationships are indicated by 90% confidence intervals that do not include zero (indicated by an asterisk). Confidence intervals are biascorrected and based on 5000 bootstrapped samples.

Model Bootstrapped
90% CI estimates
Averaged Across Pregnancy

Model 1
   Overall Stress →IL-6→ Gestational Age [−.0041, .0073]
   Overall Stress →TNF-a→ Gestational Age [−.0114, .0006]
   Overall Stress →CRP→ Gestational Age [−.0001, .0113]
Model 2
   Pregnancy Distress →IL-6→ Gestational Age [.0905, .5980]*
   Pregnancy Distress →TNF-a→ Gestational Age [−.3473, .0787]
   Pregnancy Distress →CRP→ Gestational Age [−.0197, .2987]
Early Pregnancy

Model 1
   Overall Stress →IL-6→ Gestational Age t [−.0059, .0056]
   Overall Stress →-TNF-α-→ Gestational Age [−.0174, -.0008]*
   Overall Stress →CRP→ Gestational Age [.0010, .0086]
Model 2
   Pregnancy Distress →IL-6-→ Gestational Age [.0122, .4413]*
   Pregnancy Distress →-TNF-a-→ Gestational Age [−.3221, .0039]
   Pregnancy Distress →CRP-→ Gestational Age [−.0023, .2747]
Late Pregnancy

Model 1
   Overall Stress →-IL-6→ Gestational Age [−.0068, .0034]
   Overall Stress →TNF-α-→ Gestational Age [−.0031, .0070]
   Overall Stress →CRP-→ Gestational Age [−.0009, .0084]
Model 2
   Pregnancy Distress →IL-6-→ Gestational Age [−.0144, .3258]
   Pregnancy Distress →-TNF-α-→ Gestational Age [−.1930, .2612]
   Pregnancy Distress →CRP-→ Gestational Age [−.0650, .2693]