Table 6. Results of the multiple mediation analyses of the hypothesized mediating roles of IL-6, TNF-α, and CRP in the effects of Overall Stress (Model 1) and Pregnancy-Specific Distress (Model 2) on gestational age at birth early, late, and averaged across pregnancy. Significant mediating relationships are indicated by 90% confidence intervals that do not include zero (indicated by an asterisk). Confidence intervals are biascorrected and based on 5000 bootstrapped samples.
Model | Bootstrapped 90% CI estimates |
---|---|
Averaged Across Pregnancy | |
| |
Model 1 | |
Overall Stress →IL-6→ Gestational Age | [−.0041, .0073] |
Overall Stress →TNF-a→ Gestational Age | [−.0114, .0006] |
Overall Stress →CRP→ Gestational Age | [−.0001, .0113] |
Model 2 | |
Pregnancy Distress →IL-6→ Gestational Age | [.0905, .5980]* |
Pregnancy Distress →TNF-a→ Gestational Age | [−.3473, .0787] |
Pregnancy Distress →CRP→ Gestational Age | [−.0197, .2987] |
Early Pregnancy | |
| |
Model 1 | |
Overall Stress →IL-6→ Gestational Age | t [−.0059, .0056] |
Overall Stress →-TNF-α-→ Gestational Age | [−.0174, -.0008]* |
Overall Stress →CRP→ Gestational Age | [.0010, .0086] |
Model 2 | |
Pregnancy Distress →IL-6-→ Gestational Age | [.0122, .4413]* |
Pregnancy Distress →-TNF-a-→ Gestational Age | [−.3221, .0039] |
Pregnancy Distress →CRP-→ Gestational Age | [−.0023, .2747] |
Late Pregnancy | |
| |
Model 1 | |
Overall Stress →-IL-6→ Gestational Age | [−.0068, .0034] |
Overall Stress →TNF-α-→ Gestational Age | [−.0031, .0070] |
Overall Stress →CRP-→ Gestational Age | [−.0009, .0084] |
Model 2 | |
Pregnancy Distress →IL-6-→ Gestational Age | [−.0144, .3258] |
Pregnancy Distress →-TNF-α-→ Gestational Age | [−.1930, .2612] |
Pregnancy Distress →CRP-→ Gestational Age | [−.0650, .2693] |