Table 5.
Ordinary logistic regression analysis for the associations between parameters of glycemic variability and the severity of CAN
| CAN score category† | ||||
|---|---|---|---|---|
| Univariate OR (95 % CI) | p value | Multivariate OR (95 % CI) | p value | |
| Short-term GV | ||||
| SD of glucose | 1.03 (1.01–1.06) | 0.007 | 1.02 (0.99–1.05) | 0.191 |
| MAGE | 1.01 (1.00–1.02) | 0.059 | 1.01 (0.99–1.02) | 0.398 |
| CV of glucose | 1.05 (1.00–1.10) | 0.039 | 1.05 (1.00–1.10) | 0.079 |
| Long-term GV | ||||
| SD of HbA1c | 13.79 (4.43–42.89) | <0.001 | 15.40 (4.56–52.01) | <0.001 |
| Adjusted SD of HbA1c | 18.83 (5.31–66.80) | <0.001 | 17.46 (3.86–79.06) | <0.001 |
| Log CV of HbA1c | 29.23 (5.47–156.11) | <0.001 | 27.21 (4.28–172.91) | <0.001 |
†CAN scores were categorized into 0–1.5 points (n = 62), 2–2.5 points (n = 33), and 3–5 points (n = 15)
Multivariate model was adjusted for age, sex, duration of diabetes, mean HbA1c, use of insulin, use of oral anti-diabetic drug, use of aspirin, use of beta-blocker, use of ARB/ACE inhibitor and smoking status
CAN cardiovascular autonomic neuropathy, SD standard deviation, MAGE mean amplitude of glycemic excursions, CV coefficient of variance