Table 1.

HSCT indications recommended in children (EBMT 2009) (24)

Disease	Disease status	Allogenic			Autologous
		Sibling donor	Compatible non-relative donor	>1 Ag incompatible relative and non-relative donor
AML	CR1 (low risk)	GNR	GNR	GNR	GNR
	CR1 (high risk)	S	CO	GNR	S
	CR1 (very high risk)	S	S	CO	CO
	CR2	S	S	S	S
	>CR2	CO	D	D	GNR
ALL	CR1 (low risk)	GNR	GNR	GNR	GNR
	CR1 (high risk)	S	CO	CO	GNR
	CR2	S	S	CO	CO
	>CR2	S	S	CO	CO
KML	Chronic phase	S	S	D	GNR
	Advanced phase	S	S	D	GNR
NHL	CR1 (low risk)	GNR	GNR	GNR	GNR
	CR1 (high risk)	CO	CO	GNR	CO
	CR2	S	S	CO	CO
Hodgkin’s disease	CR1	GNR	GNR	GNR	GNR
	First relapse, CR2	CO	D	GNR	S
MDS		S	S	D	GNR
Primary immune deficiencies		S	S	S	NA
Thalassemia		S	CO	GNR	NA
Sickle cell anemia (high risk)		S	CO	GNR	NA
Aplastic anemia		S	S	CO	NA
Fanconi anemia		S	S	CO	NA
Blackfan-Diamond anemia		S	CO	GNR	NA
CGD		S	S	CO	NA
Kostman syndrome		S	S	GNR	NA
MPS-1H Hurler		S	S	CO	NA
MPS-1H Hurler Scheie (severe)		GNR	GNR	GNR	NA
MPS-VI Maroteaux-Lamy		CO	CO	CO	NA
Osteopetrosis		S	S	S	NA
Ewing sarcoma (high risk or >CR1)		D	GNR	GNR	S
Soft tissue sarcoma (high risk or >CR1)		D	D	GNR	CO
Neuroblastoma (high risk)		CO	GNR	GNR	S
Neuroblastoma >CR1		CO	D	D	S
Wilms tumor >CR1		GNR	GNR	GNR	CO
Osteogenetic sarcoma		GNR	GNR	GNR	D
Brain tumors		GNR	GNR	GNR	CO

GNR: generally not recommended; S: Standard; CO: depending on the decision of the transplantation center; D: experimental; CR: complete remission; MDS: myelodisplastic syndrome; CGD: chronic granulomatous disease; AML: acute myeloid leukemia; ALL: acute lymphoblastic leukemia; KML: chronic myeloid leukemia; NHL: Non-Hodgkin lymphoma