Table 1.

Diagnostic criteria for tuberous sclerosis complex (1998)

Major findings	Minor findings
Cortical tuber Subependymal nodule Giant cell astrocytoma Hypomelanotic macules (ash-leaf sign) Shagreen patch Adenoma sebaceum (facial angiofibroma) or fibrous plaque on the forehead Numerous retinal hamartomas Ungual or periungual fibromas Rhabdomyoma in the heart Lymphangiomatosis or renal angiomyolipoma in the lung	Hypopigmented patch in the retina Hamartomatous rectal polyp Bone cyst Radial migration line in the white matter in the brain Numerous pits in the tooth enamel Gingival fibroma Extra-renal hamartoma Confetti skin lesions Multiple renal cysts

Definite diagnosis: two major or one major+two minor findings

Highly probable diagnosis: one major+one minor finding

Probable diagnosis: one major or two minor findings