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. 2014 Sep 29;105(10):1288–1298. doi: 10.1111/cas.12499

Figure 6.

Figure 6

Downregulation of miR-639 correlates with lymph node metastasis and poor patient prognosis. (a) In situ hybridization for miR-639 and immunohistochemical staining for TGFβ1 and FOXC1 were demonstrated in tongue squamous cell carcinomas (TSCC) with lymph node metastasis compared with TSCC without lymph node metastasis (original magnification, ×200). (b) Quantification of miR-639 and FOXC1 expression in TSCC with lymph node metastasis compared with TSCC without lymph node metastasis. ***P < 0.001. (c) Associations between TGFβ1 expression and miR-639 expression, and miR-639 expression and FOXC1 expression in TSCC were analyzed with Spearman order correlation. Kaplan–Meier survival curves for TSCC patients are plotted on miR-639 expression (d) or FOXC1 expression (e), and the survival difference was analyzed using the log-rank test.