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Presence of the fusion polyamide resulted in decreased androgen receptor-induced and chromosomal interactions of TMPRSS2 and ERG loci. (a, b) Following treatment of LNCaP cells with the fusion polyamide for 72 h, cells were stimulated with dihydrotestosterone (DHT) for 24 h, and FISH was performed with TMPRSS2 (green) and ERG (red) probes. (***P < 0.0001 versus negative control polyamide).
