Skip to main content
. 2014 Sep 18;105(10):1272–1278. doi: 10.1111/cas.12493

Figure 4.

Figure 4

Effect of the fusion polyamide on cell growth. The fusion polyamide reduced (a) LNCaP cell growth in an androgen-dependent manner. (b) VCaP cells and (c) PC3 cells in phenol red-free DMEM and LNCaP cells in phenol red-free RPMI medium were treated for 48 h with 5 μM of negative control polyamide (negative control) or 1 or 5 μM of pyrrole–imidazole (PI) polyamide targeting the break fusion site (fusion polyamide). After stimulation with 100 nM dihydrotestosterone (DHT), an MTS assay was performed to assess the cell proliferation rate of PI polyamide-treated cells. Results are presented as mean and SD of triplicate assays (*P < 0.05).