Table 1.

Guanine nucleotide-binding protein 1 (GBP1) immunohistochemistry and clinicopathological features of head and neck cancer

(a) Association of GBP1 expression and chemoradiotherapy resistance
		Recurrence or metastatis		Total
		+	−
GBP1	+	20	1	21	GBP1 positive cases were significantly more resistant to chemoradiotherapy than GBP1 negative cases (Behrens-Fisher test, P < 0.05). Relative risk, 1.345; 95% confidence limit, 1.022 −1.768.
	−	17	7	24
Total		37	8	45

(b) Clinicopathological features of 45 cases of head and neck cancer
Sample no.	Region	Age, years	Gender	Differentiation	TNM classification	Stage	Treatment	Total dose of irradiation (Gy)	Curative effect
GBP1(+) cases
1	Tongue	53	Male	Well	T4N2bM0	IV	Chemoradiation→operation	40	Recurrent
2	Tongue	54	Female	Well	T2N0M0	II	Chemoradiation→operation	40	Recurrent and lymph node metastasis
3	Larynx	57	Male	Moderate	T2N0M0	II	Radiation	70	Lymph node metastasis
4	Larynx	59	Male	Moderate	T2N0M0	II	Chemoradiation	70	Recurrent
5	Buccal cavity	59	Male	Moderate	T1N2 cM0	IV	Chemoradiation→operation	70	Lymph node metastasis
6	Buccal cavity	60	Male	Well	T4N2bM1	IV	Chemoradiation→operation	40	Recurrent
7	Paranasal sinus	60	Male	Well > poor	T3N0M0	III	Chemoradiation→operation	70	Recurrent and lymph node metastasis
8	Paranasal sinus	60	Male	Moderate	T3N0M0	III	Chemoradiation→operation	50	Recurrent
9	Paranasal sinus	60	Female	Moderate	T3N0M0	III	Chemoradiation→operation	50	Recurrent
10	Paranasal sinus	61	Male	Moderate	T3N0M0	III	Chemoradiation→operation	50	Lymph node metastasis
11	Larynx	67	Male	Moderate	T2N0M0	II	Radiation	72	Recurrent
12	Paranasal sinus	69	Male	Poor	T3N0M0	III	Chemoradiation→operation	50	Pathologically no recurrent/ CR over 5 years
13	Hypopharynx	69	Male	Well > moderate	T4N2 cM0	IV	Chemotherapy→operation→radiation	63	Recurrent and lung metastatis
14	Hypopharynx	71	Male	Moderate	T2N0M0	II	Chemoradiation→operation	70	Recurrent
15	Paranasal sinus	74	Male	Moderate	T4N1M0	IV	Radiation→operation	50	Recurrent
16	Paranasal sinus	75	Female	Well	T4N2bM0	IV	Chemoradiation	60	Recurrent
17	Buccal cavity	76	Male	Well	T2N0M0	II	Chemoradiation→operation	50	Lymph node and lung metastasis
18	Buccal cavity	79	Female	Well	T4N2 cM0	IV	Chemoradiation→operation	40	Recurrent and lymph node metastasis
19	Larynx	79	Male	Moderate > well	T1bN0M0	I	Radiation	66	Recurrent
20	Buccal cavity	80	Female	Well	T4N2bM0	IV	Chemoradiation→operation	60	Recurrent and lymph node metastasis
21	Larynx	81	Male	Well > moderate	T1aN0M0	I	Radiation	66	Recurrent
GBP1(−)
22	Paranasal sinus	46	Male	Well	T3N0M0	III	Chemoradiationmoradiatin	50	Recurrent and lymph node metastasis
23	Larynx	51	Male	Well	T2N0M0	I	Radiation→operation	66	Recurrent
24	Oropharynx	54	Male	Poor	T4N2 cM0	IV	Chemoradiation→operation	77	Recurrent
25	Paranasal sinus	56	Male	Moderate > well	T3N0M0	III	Chemoradiationoradia wel	70	Recurrent
26	Paranasal sinus	57	Male	Moderate	T3N0M0	III	Chemoradiation→operation	50	Recurrent
27	Oropharynx	57	Male	Moderate	T2N3M0	IV	Chemoradiation→operation	60	Recurrent
28	Paranasal sinus	57	Male	Moderate > poor	T3N2bM0	IV	Chemoradiationmoradiatpo	50	Recurrent and lymph node metastasis
29	Paranasal sinus	60	Male	Poor	T3N0M0	III	Chemoradiation→operation	50	Pathologically no recurrent/ CR over 5 years
30	Larynx	61	Male	Moderate > well	T2N0M0	II	Chemoradiation	70	Pathologically no recurrent/ CR over 5 years
31	Rhinopharynx	61	Male	Moderate	T1N2bM0	IIB	Chemoradiation→operation	70	Pathologically no recurrent/ CR over 5 years
32	Oropharynx	66	Male	Poor	T3N3M0	IV	Chemoradiation→operation	70	Pathologically no recurrent/ CR over 5 years
33	Buccal cavity	67	Male	Well	T4N2 cM1	IV	Chemoradiation→operation	40	Recurrent and lymph node metastasis
34	Tongue	68	Male	Moderate	T1N0M0	I	Radiation	70	Pathologically no recurrent/ CR over 5 years
35	Paranasal sinus	69	Male	Moderate ˜ well	T4N2bM0	IV	Chemoradiation→operation	50	Recurrent
36	Paranasal sinus	71	Male	Moderate > well	T3N0M0	III	Chemoradiation→operation	50	Pathologically no recurrent/ CR over 5 years
37	Larynx	71	Male	Well	T1N0M0	I	Radiation→operation	66	Recurrent
38	Paranasal sinus	71	Female	Well	T4N0M0	IV	Chemoradiationinustionec	50	Recurrent
39	Paranasal sinus	72	Male	Moderate	T4N0M0	IV	Chemoradiation→operation	50	Recurrent
40	Buccal cavity	74	Male	Well	T4N2bM0	IV	Chemoradiation→operation	40	Recurrent
41	Buccal cavity	75	Female	Well	T4N1M0	IV	Chemoradiation→operation	48	Recurrent
42	Paranasal sinus	76	Female	Moderate	T3N0M0	III	Chemoradiation→operation	60	Recurrent
43	Paranasal sinus	77	Male	Moderate	T4N0M0	IV	Chemoradiation→operation	50	Recurrent
44	Tongue	80	Male	Well	T2N0M0	II	Radiation	70	Recurrent
45	Larynx	82	Male	Well	T1N0M0	I	Radiation	66	Pathologically no recurrent/ CR over 5 years

CR, complete remission; GBP1, guanine nucleotide-binding protein 1.