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. 2014 Sep 25;105(10):1343–1350. doi: 10.1111/cas.12490

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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In vivo effect of CF172 against peritoneal metastasis of CXC chemokine receptor-4 (CXCR4)-expressing rhabdomyosarcoma model. (a) The anti-peritoneal metastasis activity of CF172 against SJCRH30-luc cells was evaluated based on photon detection using bioimaging. SJCRH30-luc cells were i.p. inoculated into nude mice. On the same day, CF172 (25 mg/kg) was i.v. injected in a single shot. After 5 days, metastasized tumor cells were measured by administration of luciferase substrate and detection of the photons. Data were individually plotted by the percentage change from initial photon concentrations. Statistical tests were carried out using Student's t-test. (b) Photographs of all mice on day 5.