Figure 6.
In vivo effect of CF172 against tumor growth and lymph node metastasis of CXC chemokine receptor-4 (CXCR4)-expressing rhabdomyosarcoma model. (a) Antitumor activity activity of CF172 against SJCRH30-luc cells was evaluated using s.c. implanted SJCRH30-luc cells. Once the tumors had reached a volume of approximately 100 mm3, mice were randomly assigned to two groups (n = 5) and twice-weekly i.v. injection of CF172 (25 mg/kg) was carried out for 14 days. The mean tumor volume is shown. Black triangle indicates treatment day. (b) The anti-metastasis activity of CF172 against lymph node metastasis of SJCRH30-luc was evaluated by detection of photons from lysed lymph nodes. Statistical tests were carried out using the Wilcoxon test.