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Estrogen receptor (ER)-mediated transcription involving FOXA1. FOXA1 interacts with cis-regulatory regions in heterochromatin and in combination with adjacent DNA binding elements, such as estrogen response elements, to facilitate the interaction of ER with chromatin. Subsequent to the association with ER, the recruitment of cofactors occurs at these distal enhancer sites and the transcription of the target gene is initiated.
