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. 2014 Oct 29;105(11):1377–1383. doi: 10.1111/cas.12521

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig 4 — Schematic representation of different estrogen receptor (ER) binding events involving FOXA1 facilitating the transcription of different genes. The different ER binding events at distinct cis-regulatory elements ocurr with FOXA1 in different situations. For example, situations 1 (a) and 2 (b). The different ER binding at distinct cis-regulatory elements is functionally and biologically relevant, resulting in altered gene expression profiles that contribute to differences in the endocrine response and outcome. (a) Situation 1. Endocrine-responsive breast cancer with a good outcome, for example, ER positive/progesterone receptor (PR) positive/HER2 negative tumors. (b) Situation 2. Endocrine-resistant breast tumor with a poor prognosis, for example, ER positive/PR positive/HER2 positive or ER positive/PR negative/HER2 negative, or with active growth factor receptor (GFR) signaling.