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. 2014 Oct 18;105(11):1457–1463. doi: 10.1111/cas.12532

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig 3 — Hypermethylation-induced downregulation of YBX3 in the Cancer Genome Atlas Research Network acute myeloid leukemia cohort. (a) ZRSR2 and YBX3 promoters were hypermethylated in 7/173 (4.0%) and 11/173 (6.4%) acute myeloid leukemia cases, respectively. Promoter hypermethylation was not detected in other splicing factors. (b) YBX3 promoter hypermethylation was significantly associated with the loss of YBX3 mRNA expression (P < 0.0001). (c) Promoter hypermethylation of ZRSR2 was not associated with expression levels of ZRSR2 mRNA (P = 0.1204). RSEM, RNA-Seq by Expectation Maximization.