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. 2014 Nov 7;105(11):1503–1509. doi: 10.1111/cas.12535

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fig 3 — Absence of intratumoral androgenic enzymes was significantly correlated with adverse clinical outcome in breast cancer patients. Clinical information regarding overall survival (OS) and disease-free survival (DFS) was available for cases from Tohoku University Hospital and Tohoku Kosai Hospital. Only patients with survival data greater than 5 years (surgical date before 2008) were included in this study. The OS (a) and DFS (b) of these patients were analyzed according to the status of intratumoral androgenic enzymes 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5) and 5α-reductase type 1 (5αRed1) using the Kaplan–Meier method (n = 72).