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. 2014 Sep 3;105(9):1093–1099. doi: 10.1111/cas.12484

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© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig 4 — Inhibition of ten-eleven translocation (TET)-mediated DNA demethylation processes by mutant isocitrate dehydrogenase (IDH)1/2. 2-Hydroxyglutarate (2-HG) competitively inhibits the function of α-ketoglutarate (α-KG)-dependent enzymes such as TET2 and histone demethylases like JMJD3 or FBXL11/KDM2A. IDH1/2*, mutant IDH1 and mutant IDH2; K^me, methylated lysine; 5-mC, 5-methylcytosine; TCA, tricarboxylic acid.