Fig 4.

High alternative polyadenylation (APA) scores were correlated with a poor prognosis, loss of PABPN1 and CPEB1, and gain of MKI67, TOP2A and MCM2. Kaplan–Meier curves are shown for APA score (a) and PABPN1 expression (b). The cutoff value of the APA score was determined to be 5 by receiver-operating characteristic curve analysis and the median expression value of PABPN1 was used as the threshold to divide the patients into two groups. Comparison between the two groups was performed using the log-rank test.