Table 3.
Results of multivariate analyses carried out to determine the independent prognostic factors in patients with resected non-small cell lung cancer
| Test set (n = 100) | ||
|---|---|---|
| Hazard ratio | P | |
| APA score ≥5 | 3.0 | 0.03 |
| T2, T3 | 2.6 | NS |
| N1, N2 | 4.7 | 0.002 |
| Age ≥70 years | 0.3 | 0.02 |
| Male | 1.0 | NS |
| Positive smoking history | 2.2 | NS |
| Non-adenocarcinoma | 1.6 | NS |
| Test set (n = 100) | ||
|---|---|---|
| Hazard ratio | P | |
| Loss of PABPN1† | 3.5 | 0.01 |
| Loss of CPEB1† | 2.1 | NS |
| Gain of MKI67† | 1.7 | NS |
| Gain of TOP2A† | 2.1 | NS |
| Gain of MCM2† | 0.4 | NS |
| Gain of E2F1† | 3.9 | 0.02 |
†
The median expression value of each gene was used as the threshold to divide the patients into two groups; those with either loss or gain of expression. APA, alternative polyadenylation; NS, not significant.