TABLE 2.
Absolute categorical agreement and error rates when the azole surrogate fluconazole result was used to predict ravuconazole susceptibility of Candida spp.
| Organism(s) tested | No. of isolates | Rate (%) of:
|
|||
|---|---|---|---|---|---|
| Agreement | VME | ME | Minor errors | ||
| All Candida | 12,796 | 92.5 (94.7)a | 0.1 (0.1)a | 1.4 (0.5)a | 6.0 (4.7)a |
| C. albicans | 7,521 | 99.1 | 0.1 | 0.3 | 0.5 |
| C. glabrata | 1,869 | 73.0 (97.1)b | 0.3 (1.9)b | 1.0 (1.0)b | 25.7 (0.0)b |
| C. parapsilosis | 1,485 | 96.6 | 0.0 | 0.5 | 2.9 |
| C. tropicalis | 1,185 | 99.1 | 0.1 | 0.1 | 0.8 |
| C. krusei | 302 | 3.3 | 0.0 | 39.7 | 57.0 |
| C. lusitaniae | 128 | 96.9 | 0.0 | 0.8 | 2.3 |
| C. dubliniensis | 103 | 93.2 | 0.0 | 1.0 | 5.8 |
| C. guilliermondii | 84 | 90.5 | 2.4 | 0.0 | 7.1 |
| C. pelliculosa | 34 | 100 | 0.0 | 0.0 | 0.0 |
| C. kefyr | 28 | 100 | 0.0 | 0.0 | 0.0 |
| C. rugosa | 19 | 79.0 (100)b | 0.0 (0.0)b | 0.0 (0.0)b | 21.0 (0.0)b |
| C. famata | 16 | 75.0 (100)b | 0.0 (0.0)b | 0.0 (0.0)b | 25.0 (0.0)b |
a
The value in parentheses is based on results for all Candida minus C. krusei (12,494 isolates).
b
The value in parentheses was obtained by using the following categories for fluconazole: susceptible, MIC ≤ 32 μg/ml (S and S-DD combined); resistant, MIC ≥ 64 μg/ml.