Table 4.
Predicted 3-year change in ADAS-cog stratified by optimal cut points of predictors*
| 3-year % Change in ADAS-Cog | p value | |
|---|---|---|
| Cognitive test | ||
| Animal fluency | ||
| <22 (n = 110) | 12.4 | <0.0001 |
| ≥22 (n = 81) | −0.2 | 0.96 |
| Brain volumetric measures | ||
| Whole-brain volume | ||
| <1,080,000mm3 (n = 104) | 14.8 | <0.0001 |
| ≥1,080,000mm3 (n = 87) | 0 | 0.99 |
| L-hippocampal volume, mm (n = 186) | ||
| <3,600 mm3 (n = 88) | 14.2 | <0.0001 |
| ≥3,600 mm3 (n = 98) | 2.1 | 0.45 |
| R hippocampal volume, mm (n = 186) | ||
| <3,700 mm3 (n = 95) | 13.5 | <0.0001 |
| ≥3,700 mm3 (n = 91) | 1.9 | 0.51 |
| Cerebrospinal Fluid | ||
| Total tau (n = 188) | ||
| ≥61 (n = 91) | 13.6 | <0.0001 |
| <61 (n = 91) | 1.3 | 0.68 |
| p-tau | ||
| ≥21 (n = 89) | 13.1 | <0.0001 |
| <21 (n = 102) | 1.4 | 0.64 |
| Aβ42 | ||
| <220 (n = 90) | 16.7 | <0.0001 |
| ≥220 (n = 101) | −0.2 | 0.95 |
| Total tau/Aβ42 ratio (n = 188) | ||
| ≥0.31 (n = 89) | 16.0 | <0.0001 |
| <0.31 (n = 99) | 0.1 | 0.98 |
| p-tau/Aβ42 ratio | ||
| ≥0.10 (n = 85) | 16.1 | <0.0001 |
| <0.10 (n = 106) | 0.4 | 0.88 |
*
Based on iteratively choosing cut points for each individual marker, and running survival analyses for each of the two resulting groups, in which 3-year percent change is predicted via the coefficient for ‘time’. All models adjusted for age, race, gender, education, and APOE status.