| Dex |
Rate of CRY/PER mRNA synthesis by dexamethasone |
0 |
0 |
| kms
|
Rate of CRY/PER mRNA synthesis |
0 |
1 |
| J |
Michaelis constant for BMAL1/CLOCK binding to CRY/PER promoter |
0 |
0.3 |
| kmd
|
Rate of CRY/PER mRNA degradation |
0.13857 |
0.1 |
| kcps
|
Rate of CRY/PER protein synthesis |
0.40453 |
0.5 |
| kcpd
|
Rate of CRY/PER protein degradation |
0.48936 |
0.525 |
| ka
|
Rate of CRY/PER dimer association |
49.9712 |
100 |
| kd
|
Rate of CRY/PER dimer disassociation |
0.36005 |
0.01 |
| kp1
|
Rate for monomer phosphorylation |
9.4531 |
10 |
| Jp
|
Michaelis constant of protein kinase (Casein Kinase 1 Epsilon, CSNK1E) |
77.9254 |
0.05 |
| kchk2
|
Rate of phosphorylation by CHK2 |
0 |
0 |
| kicd
|
Rate of inactive complex (BMAL1/CLOCK/(CRY/PER)/(CRY/PER)) degradation |
0 |
0.01 |
| kcp2d
|
Rate of CRY/PER dimer degradation |
0.0025 |
0.0525 |
| kica
|
Rate of inactive complex association |
28.178 |
20 |
| kchk2c
|
Rate of phosphorylation by CHK2 |
0 |
0 |
| kp2
|
Rate for dimer phosphorylation |
0.36296 |
0.1 |
| Tftot
|
Total amount of BMAL1/CLOCK |
0.84792 |
0.5 |
| KTFCP
|
Binding affinity of BMAL1/CLOCK to CRY/PER promoter |
0.020133 |
0 |
| KCP2CP
|
Binding affinity of CRY/PER dimer to CRY/PER promoter |
0.20757 |
0 |
| KTFNP
|
Binding affinity of BMAL1/CLOCK to NAMPT promoter |
0.040267 |
0 |
| KCP2NP
|
Binding affinity of CRY/PER dimer to NAMPT promoter |
0.21591 |
0 |
| kcpdeac
|
Rate of CRY/PER promoter deacetylation |
0.099 |
0 |
| knpdeac
|
Rate of NAMPT promoter deacetylation |
0.098073 |
0 |
| VM |
Rate of CRY/PER expression |
0.40053 |
0 |
| VN |
Rate of NAMPT expression |
0.56383 |
0 |
| n |
Hill coefficient for CRY/PER mRNA synthesis |
0 |
2 |
| nac
|
Value used to describe the steady state values for promoter accessibility |
1.6107 |
0 |
| Tconst_np
|
Time constant for the relaxation of NAMPT promoter to steady state value |
0.26014 |
1 |
| Tconst_cp
|
Time constant for the relaxation of CRY/PER promoter to steady state value |
0.22107 |
1 |
| VSIRT1c |
Rate of SIRT1 activity (non-histone deacetylation) |
0.094568 |
0 |
| knadd
|
Rate of NAD+ degradation |
1.3309 |
0 |
| knd
|
Rate of NAMPT mRNA degradation |
0.16337 |
0 |
| knps
|
Rate of NAMPT protein synthesis |
0.20238 |
0 |
| knpd
|
Rate of NAMPT protein degradation |
0.16024 |
0 |
| VNADc |
Rate of NAD+ production |
5.2479 |
0 |
| kaCPSIRT1
|
Disassociation constant of SIRT1 and NAD+ (Used with non-histone-related equations) |
0.10491 |
0 |
| kbCPSIRT1
|
Michaelis constant for non-histone substrates |
0.098395 |
0 |
| kPARP
|
Rate of PARP1 activity |
0 |
0 |
| VSIRT1d |
Rate of SIRT1 activity (histone deacetylation) |
0.070926 |
0 |
