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. 2015 Apr 7;5(4):e541. doi: 10.1038/tp.2015.33

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Prenatal serum- and LPA exposure alters gene expression profiles relevant to schizophrenia in adult animals. RNA was isolated from female adult prefrontal cortex (Bregma coordinates 2.50–1.30) and midbrain (Bregma coordinates −3.00 to −4.20) and gene expression changes were assessed by microarray analyses (n=5 per group). (a) Gene networks of greatest relevance were related to developmental disorder, gene expression, lipid metabolism and synaptic activity in the prefrontal cortex (as determined by Ingenuity Pathway Analysis software). (b) Venn diagram illustrating overlap between genes altered with serum/LPA exposure and schizophrenia-related genes in the combined midbrain and prefrontal cortex. (c and d) RT-PCR (PCR with reverse transcription) validation of selected genes (n=3, mean±s.e.m., Student's t-test, ^*P<0.05). LPA, lysophosphatidic acid.