Table 3. Top 10 association regions from the genome-wide association meta-analysis of the combined ISPC+AMPS sample and STAR*D (all race).

Outcome measure	SNP	CHR	BP	Gene	ISPC+AMPS Beta/OR	STAR*D Beta/OR	Meta-analysis Beta/OR	P
% Change in depression score	rs6889896	5	124699239	LOC644659	−0.17	−0.16	−0.17	5.49E−07
	rs35806662	2	158790425	LOC100130766	−0.18	−0.21	−0.20	6.47E−07
	rs73069924	5	32278233	MTMR12	−0.50	−0.42	−0.44	8.09E−07
	rs4615376	6	13071073	PHACTR1	−0.20	−0.13	−0.16	1.05E−06
	rs2566255	11	4605195	OR52I2/C11orf40	0.24	0.26	0.26	1.51E−06
	rs910039	6	17505944	CAP2	0.10	0.17	0.13	2.11E−06
	rs17068112	6	139250125	REPS1	0.19	0.37	0.26	3.28E−06
	rs7485210	12	131638853	LOC116437	0.18	0.10	0.14	3.42E−06
	rs74378198	5	38870908	OSMR	−0.69	−0.37	−0.43	3.77E−06
	rs4236420	7	9688109	PER4	0.10	0.17	0.13	4.08E−06
Response	rs2456568	11	93691332	HPRTP4	1.43	1.29	1.36	5.03E−08
	rs113889867	8	80556500	STMN2	0.67	0.42	0.51	8.68E−07
	rs10954808	8	31479623	NRG1	0.73	0.73	0.73	1.20E−06
	rs506546	1	34439294	CSMD2	0.70	0.83	0.76	1.46E−06
	rs74546197	1	205880179	SLC26A9	0.45	0.47	0.46	3.21E−06
	rs72772787	1	248016378	TRIM58	2.63	1.94	2.34	3.96E−06
	rs2043144	9	73950955	TRPM3	0.33	0.42	0.38	4.30E−06
	rs291028	15	95615786	LOC400456	0.61	0.60	0.61	5.02E−06
	rs7051085	23	23374977	PTCHD1	0.60	0.69	0.63	5.51E−06
	rs1210638	22	18981563	DGCR5	1.34	1.32	1.33	6.04E−06

Abbreviations: AMPS, Antidepressant Medication Pharmacogenomics Study; Beta/OR, regression parameter estimates (beta) for SNP effect on quantitative trait outcome or odds ratio (OR) estimate for SNP effect on binary outcome; ISPC, International SSRI Pharmacogenomics Consortium; SNP, single-nucleotide polymorphism; STAR*D, Sequenced Treatment Alternatives to Relieve Depression.

Rather than showing results for multiple SNPs in one region, only one (top) SNP is shown for each association region. There were other SNPs in these regions with suggesting evidence for association, for example, in the chromosome 11 region near HPRTP4, there were 34 SNPs with P<10⁻⁶.