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F. novicida BplA is required for replication in mice. Mice were infected subcutaneously with 1 × 105 CFU of wild-type F. novicida U112 (WT) or the ΔbplA or ΔbirA strain. At 48 h postinfection, skin samples obtained at the site of infection as well as the spleen and liver were harvested, and CFU were enumerated after plating. ***, P < 0.0005.
