Table 2.
Multivariable Poisson Model Evaluating Predictors of Kaposi Sarcoma Including Time on Combination Antiretroviral Therapy in a Cohort of 25 529 Male Human Immunodeficiency Virus–Positive Veterans
| Parameter | Incidence Rate Ratio (95% Confidence Interval) | P Value |
|---|---|---|
| Age at HIV diagnosis (y) | ||
| <30 | 1.0 (Ref) | |
| 30–39 | 0.82 (.58–1.17) | .27 |
| 40–49 | 0.52 (.36–.76) | <.001 |
| 50–59 | 0.58 (.37–.90) | .02 |
| ≥60 | 0.70 (.38–1.28) | .25 |
| Race/Ethnicity | ||
| White | 1.0 (Ref) | |
| Black | 0.77 (.60–.97) | .03 |
| Hispanic | 1.01 (.68–1.51) | .95 |
| Unknown | 0.63 (.27–1.44) | .27 |
| Deyo comorbidity score | ||
| 0 | 1.0 (Ref) | |
| 1 | 0.73 (.57–.94) | .02 |
| ≥2 | 0.95 (.71–1.26) | .70 |
| Clinic visits per year | ||
| <4 | 1.0 (Ref) | |
| 4–5 | 1.01 (.66–1.52) | .98 |
| 6–9 | 0.94 (.65–1.36) | .73 |
| 10–19 | 1.21 (.85–1.73) | .28 |
| ≥20 | 1.46 (.96–2.22) | .08 |
| % of time on cART | ||
| <80% | 1.0 (Ref) | |
| 80%–100% | 0.71 (.55–.92) | <.001 |
| Era of HIV diagnosis | ||
| Pre-cART (before 1996) | 1.0 (Ref) | |
| Early cART (1996–2002) | 0.92 (.73–1.17) | .49 |
| Late cART (2003–2010) | 0.45 (.28–.72) | <.001 |
| Lowest CD4 count before cART | ||
| CD4 <200 | 1.0 (Ref) | |
| CD4 200–350 | 1.33 (1.02–1.74) | .03 |
| CD4 >350 | 1.11 (.77–1.59) | .58 |
| CD4 count at event/censor | ||
| CD4 <200 | 1.0 (Ref) | |
| CD4 200–350 | 0.41 (.31–.55) | <.0001 |
| CD4 >350 | 0.26 (.19–.36) | <.0001 |
| HIV viral load | ||
| Detectable (≥500) | 1.0 (Ref) | |
| Undetectable (<500) | 0.43 (.33–.56) | <.0001 |
| Time from initiating cART | ||
| <1 y | 1.75 (1.27–2.40) | <.001 |
| 1–2 y | 1.33 (.96–1.85) | .09 |
| 2–3 y | 1.22 (.86–1.72) | .26 |
| ≥3 y | 1.0 (Ref) | |
Abbreviations: cART, combination antiretroviral therapy; HIV, human immunodeficiency virus; Ref, reference.