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editorial
. 2015 Jun 14;21(22):6794–6808. doi: 10.3748/wjg.v21.i22.6794

Table 4.

Data derived from the main published studies that have correlated functional radiological techniques with response to systemic therapies of hepatic and pancreatic tumors

Study n Technique Imaging biomarker Histotype Treatment
Lewin et al[107] 12 IVIM f increase HCC sorafenib
Vouche et al[108] 15 DWI ADC increase HCC 90Y TARE ± sorafenib
Hsu et al[109] 31 DCE-MRI Ktrans decrease HCC sorafenib+metronomic tegafur/uracil
Yopp et al[111] 17 DCE-MRI AUC90/AUC180/Ktrans decrease HCC bevacizumab
Jiang et al[112] 23 pCT BF/BV/PS decrease HCC bevacizumab + cytotoxic agents
MTT increase
Kim et al[113] 10 DCE-MRI/DWI Ktrans/Kep decrease HCC sunitinib
ADC increase
Sahani et al[114] 23 DCE-MRI/DWI Ktrans/Kep decrease HCC sunitinib
ADC increase
Kim et al[123] 35 pCT BF decrease CRC metastases XELOX, FOLFOX, FOLFIRI
Schlemmer et al[124] 24 pCT Perfusion decrease PanNET metastases Tyrosine-kinase inhibitors
Anzidei et al[125] 18 pCT, DWI CP decrease CRC metastases Oxaliplatinum, capecitabine, bevacizumab
ADC increase
De Bruyne et al[127] 19 DCE-MRI AUC decrease CRC metastases Bevacizumab
Vriens et al[129] 23 DCE-MRI Ktrans decrease CRC metastases Cytotoxic therapy
Coenegrachts et al[130] 10 DCE-MRI Kep increase CRC metastases Bevacizumab + FOLFIRI
Deckers et al[126] 20 DWI ADC decrease CRC metastases Chemotherapy
Niwa et al[133] 63 DWI ADC decrease PDAC Gemcitabine
Cuneo et al[134] 12 DWI ADC increase PDAC Chemoradiation
Yao et al[135] 39 pCT BF decrease PanNET Bevacizumab ± everolimus
Miyazaki et al[132] 20 DCE-MRI Distribution volume increase PanNET metastases 90Y-octretotide

n: Number of patients; IVIM: Intravoxel incoherent-motion diffusion-weighted imaging; f: Perfusion fraction; HCC: Hepatocellular carcinoma;

90

Y TARE: 90Yttrium trans-arterial radioembolization; DWI: Diffusion-weighted imaging; ADC: Apparent diffusion coefficient; DCE-MRI: Dynamic contrast-enhanced MRI; Ktrans: Volume transfer constant; AUC90, AUC180: Area under the curve at 90 and 180 s; pCT: Perfusion computed tomography; BF: Blood flow; BV: Blood volume; PS: Permeability surface; MTT: Mean transit time; Kep: Rate constant; CP: Capillary permeability.