Table 4.
Results of the multivariate model for the matrix and fiber stiffness with age, diabetes diagnostic, and age–diabetes interaction as explanatory variables. The age–diabetes interaction was not significant for the matrix stiffness (p = 0.28) and fiber stiffness (p = 0.08).
| Outcome | Variable | Estimate (95% CI) | p value |
|---|---|---|---|
| Matrix stiffness μ (kPa) | Age (per 10-yr increase) | ||
| Specimen with a history of diabetes | 76.4 (24.1, 128.8) | 0.01 | |
| Specimen with no history of diabetes | 40.8 (−6.8, 88.4) | 0.08 | |
| Diabetes | 0.01 | ||
| Yes | 130.6 (34.5, 226.6) | ||
| No (ref) | 0 | ||
| Fiber stiffness 4αβ (MPa) | Age (per 10-yr increase) | ||
| Specimen with a history of diabetes | 2.27 (−0.15, 4.69) | 0.06 | |
| Specimen with no history of diabetes | −0.52 (−2.72, 1.69) | 0.60 | |
| Diabetes | 0.92 | ||
| Yes | −0.19 (−4.63, 4.25) | ||
| No (ref) | 0 |
p values in bold indicate statistical significance.