Table 5.
Results of the multivariate model with compound symmetry correlation for mechanical anisotropy in the peripapillary sclera with age, quadrant, diabetes diagnostic, and age–diabetes interaction as explanatory variables. The age–diabetes interaction was not significant (p = 0.11). The variogram was flat for the mechanical anisotropy, indicating little or no spatial correlation. Mechanical anisotropy measurements from the same specimen were assumed to have the same correlation regardless of the distance between them. S stands for superior, N for nasal, I for inferior, and T for temporal. Observed mean mechanical anisotropy was 1.09 ± 0.68 in the NI, 1.06 ± 0.71 in the IT, 1.23 ± 0.77 in the TS, and 0.95 ± 0.58 in the SN.
| Mechanical anisotropy | ||
|---|---|---|
| Variable | Estimate (95% CI) | p value |
| Age (per 10-yr increase) | ||
| Specimen with a history of diabetes | 0.037 (−0.459, 0.534) | 0.87 |
| Specimen with no history of diabetes | −0.487 (−0.939, −0.035) | 0.04 |
| Diabetes | 0.24 | |
| Yes | −0.5 (−1.42, 0.41) | |
| No (reference) | 0 | |
| Region: | <0.0001 | |
| NI | −0.150 (−0.249, −0.051) | |
| IT | −0.180 (−0.278, −0.081) | |
| SN | −0.301 (−0.400, −0.202) | |
| TS (reference) | 0 | |
p values in bold indicate statistical significance.