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. 2015 Jun 15;26(12):2227–2241. doi: 10.1091/mbc.E15-01-0026

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© 2015 Karg, Warecki, and Sullivan. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/bync-sa/3.0).

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FIGURE 3: — X-ray–induced acentric chromosome fragments also enter nascent daughter nuclei through highly localized delays in assembly of the nuclear envelope. (A) Time-lapse images of acentric fragments in the neuroblast division of an x-irradiated larva expressing H2Av-RFP (red) and lamin B-GFP (green). Acentrics resulting from x-irradiation (red arrows) enter the daughter nuclei through a gap in the nuclear envelope (green arrow). Initiation to completion of NEF requires 220 s. (B) A still frame from a time-lapse movie of a nuclear envelope gap forming in a telophase nucleus with irradiation-induced acentrics (different neuroblast than shown in A) expressing H2Av-RFP (red) and lamin B-GFP (green). As seen in A, the irradiation-induced acentric (red arrow) rejoins the main nuclear mass by entering the nucleus through a gap in the nuclear envelope (green arrow). (C) Graphical representation quantifying the percentage of irradiated neuroblasts that had chromosome segregation defects (gray bar), the percentage of neuroblasts with chromosome segregation defects that were acentrics (red bar), and the percentage of neuroblasts with acentrics that formed nuclear envelope gaps (blue bar).