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Schematic diagram that illustrates the ELMOD2 function on ATGL transport. The active Arf1-COPI complex in LDs is thought to facilitate budding of nanodroplets, thereby increasing the surface tension of the LD surface. This likely induces the formation of ER–LD membrane bridges through which ATGL is recruited to LDs. The Arf-GAP activity of ELMOD2 likely down-regulates these processes by inactivating Arf1 in LDs.
