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. 2015 Jun 11;9:29. doi: 10.3389/fncir.2015.00029

Figure 2.

Figure 2

Convergence of the neuronal response latency to stabilization without adaptive external feedback, and asymmetry between facilitation and depression. (A) The NRL, L, of a cultured neuron stimulated at τ = 198.2 ms between stimulations (blue), with an estimated LST of 4.97 ms (Figure 1C, middle panel), smoothed using 1000 Stimulation sliding window. (B) ln (LST-L) using the estimated LST (blue). The fit in the range of [1200, 8073] stimulations (red) indicates a convergence to LST as LST-L~0.06·exp(−0.0002·Stimulation). (C) The NRL, L, of a neuron stimulated at τ = 117 ms between stimulations, where at stimulations (2n + 1)·100 τ = 197 ms and at (2n + 2)·100 τ = 37 ms, where n,1,.… Results indicate an asymmetry between facilitation, with an amplitude of ~0.4 ms in case τ decreased, and depression, with an amplitude of ~0.1 ms in case τ increased (see zoom-in, gray). (D) Same as (C) but with moderate changes in τ, at stimulations (2n + 1)·100 τ = 150 ms and at (2n + 2)·100 τ = 84 ms. Results indicate an asymmetry between facilitation, with an amplitude of ~0.2 ms in case τ decreased, and depression, with an amplitude of ~0.1 ms in case τ increased (see zoom-in, gray).