Table 1.
Characteristics of innate T cells.
TCR | Human: Vα24-Jα18 | Human: Vα7.2-Jα33 | Human: Vδ1, Vδ3, Vγ9vδ2 |
Mouse: Vαl4-Jα18 | Mouse: Vαl9-Jα33 | Mouse: VγlVδ6.3, Vγ5Vδ1, Vγ6Vδ1 | |
Ligand | Glycolipids, phospholipids | Vitamin B2 metabolites, transitory neo-antigens | Phosphoantigens, phycoerythrin, glycolipids |
Frequency | Low (0.01–1% of T cells) | 1–20% of T cells | 2–10% of T cells |
Location | Blood, mucosal site, and liver | Blood, gut, lung, liver | Blood, mucosal sites |
Maturation | Thymus | Secondary lymphoid tissue | Thymus |
Present at birth | Yes | Yes | Yes |
HSCT | Yes | ? | Poor |
?, information not known.