Table 1.
Changes in Lymphocyte Populations From Autologous Stem Cell Transplant to Resolution of Viremia
| Days Post-Transplant |
||||
|---|---|---|---|---|
| −41 | 21 | 42 | 472 | |
| Viral load | <50 | 940 | <50 | <50 |
| Percentage of live lymphocytes | ||||
| NK cells (CD56+)a | 0.18 | 1.51 | 1.58 | 2.29 |
| Of which CD16+CD56bright | ND | 0.68 | 2.69 | 2.20 |
| Of which CD16+CD56dim | ND | 77.7 | 84.8 | 81.4 |
| Of which CD16−CD56bright | ND | 1.02 | 2.28 | 4.00 |
| Of which CD16−CD56dim | ND | 22.6 | 11.2 | 0.00 |
| NKT-like cells (CD3+CD56+) | 2.30 | 3.27 | 2.01 | 1.59 |
| CD3 T cells (CD3+CD56−) | 92.8 | 86.4 | 96.0 | 88.6 |
| CD8 T cells (CD3+CD8+) | 23.4 | 69.1 | 74.1 | 46.5 |
| B cells (CD3−CD19+) | 0.00 | 0.06 | 0.12 | 2.25 |
| Proliferation: % Ki67+ | ||||
| NK cells | 92.5 | 92.1 | 81.5 | 10.5 |
| NKT cells | 58.3 | 63.0 | 75.3 | 3.20 |
| CD8+ T cells | 100 | 99.7 | 99.8 | 1.62 |
| CD4+ T cells (CD3+CD8−CD56−) | 90.9 | 90.5 | 99.0 | 1.77 |
| B cells | ND | 50.0 | 39.5 | 4.24 |
Lymphocyte populations were assessed by flow cytometry and are shown as a percentage of the total live cells (as determined by an amine-reactive viability dye) present in each sample. Autologous stem cells for day −41 or peripheral blood mononuclear cell for days 21,42, and 472.
Abbreviations: ND, not determined due to too few cells in the parent gate for analysis; NK, natural killer.
a Defining markers for each population are shown in parentheses.