TABLE 4.
Overview of countries’ guidelines and implementation status regarding ‘old’ versus ‘new’ WHO dosage recommendations
| Country | Guidelines include 2010 Rapid Advice | Dosage recommendations for childhood TB (guidelines) | Imple-mentation of Rapid Advice started? | Imple-mentation planned? |
| Afghanistan | WHO 2006 | Yes | ||
| Bangladesh | Yes | WHO 2010 | Yes | |
| Bhutan | Yes | WHO 2010 | Yes | |
| Brazil | WHO 2010 | Yes* | ||
| Burkina Faso | Yes | WHO 2010 | Yes | |
| Colombia | Yes | WHO 2010 | Yes | |
| Côte D’Ivoire | WHO 2006 | No | ||
| Djibouti | Yes | WHO 2006 | No | Yes |
| Ecuador | WHO 2006 | No | Yes | |
| Egypt | WHO 2006 | No | Yes | |
| Ethiopia | Yes | WHO 2010 | Yes | |
| Germany | Yes | Age- or body surface area-adjusted dosages | No† | No comment |
| India | Thrice-weekly intermittent | No | No with exception‡ | |
| Indonesia | Yes | WHO 2010 (adapted)§ | Yes | |
| Iraq | Yes | WHO 2006 | No | Yes |
| Italy | Dose-range | No | No comment | |
| Lebanon | WHO 2006¶ | No | No comment | |
| Lesotho | WHO 2010 | No | Yes | |
| Malawi | Yes | WHO 2006 | No | Yes |
| Morocco | Yes | WHO 2010 | Yes | |
| Myanmar | WHO 2006 | Yes | ||
| Nepal | Yes | WHO 2010 | Yes | |
| Niger | Yes | WHO 2010 | Yes | |
| Oman | Yes | WHO 2010 | Yes | |
| Pakistan | Yes | WHO 2010 | Yes | |
| Senegal | Yes | WHO 2010 | No | Yes |
| Somalia | WHO 2006 | No | Yes | |
| Sri Lanka | WHO 2006 | No | No | |
| Sweden | WHO 2010 | Yes | ||
| Syria | WHO 2010 modified# | Yes | ||
| Timor Leste | WHO 2006 modified** | No | Yes | |
| Tunisia | Yes | WHO 2010 | No | Yes |
| Uganda | Yes | WHO 2010 | No | No comment |
| Zimbabwe | Yes | WHO 2010 | Yes |
Brazil: dose-range recommended for R (10–20 mg).
Germany: adjusted dosage recommendations, partly reaching levels recommended in Rapid Advice, were already in place.
India: dosages for intermittent therapy will be increased and daily therapy introduced during the intensive phase for seriously ill children while admitted to hospital (http://tbcindia.nic.in/Paediatric%20guidelines_New.pdf).
Indonesia: lower dosage recommendation for Z (15–30 mg) and E (15–20 mg).
Guidelines according to WHO 2006, but most dosages recommended and prescribed by private paediatricians.
Syria: lower dosage recommendation for Z (25 mg/kg).
Timor Leste: lower dosage recommendation for E (15 mg/kg).
WHO = World Health Organization; TB = tuberculosis; R = rifampicin; Z = pyrazinamide; E = ethambutol.