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. 2015 Apr 6;125(5):1944–1954. doi: 10.1172/JCI78490

Figure 2. 12/15-LO regulates the maturation process of DCs.

Figure 2

Flow cytometry–based analysis of (A) the expression of MHC class II molecules (MHCII) or (B) the expression of the indicated costimulatory molecules on WT (Alox15+/+) and Alox15–/– CD11c+ BM-DCs after LPS-induced maturation (100 ng LPS/ml). (C) Comparison of surface marker expression levels on CD11c+ BM-DCs by mean fluorescence intensity. (D) Effect of the 15-LO inhibitor Baicalein on the expression of the indicated surface molecules on human moDCs in the absence and presence of maturation (mat) cocktail. Data are representative of at least 3 independent experiments (n = 3). Error bars represent SEM. *P < 0.05, **P < 0.005, Student’s t test.