Skip to main content
. 2015 Apr 6;125(5):1944–1954. doi: 10.1172/JCI78490

Figure 4. NRF2 mediates the immune-modulatory effects of 12/15-LO–derived oxidized phospholipids.

Figure 4

(A) ChIP-based analysis of the binding of NRF2 to the Nqo1 and Hmox1 promoter in WT and Alox15–/– DCs. (B) ChIP-based analysis of the oxPC-induced binding of NRF2 to the Nqo1 and Hmox1 promoter in WT and Nrf2–/– DCs. (C) oxPC-induced expression of Nqo1, Hmox1, and Gclc mRNA expression in WT and Nrf2–/– DCs. (D) Flow cytometry-based quantification of the oxPC-induced inhibition of the expression of the indicated surface molecules on WT and Nrf2–/– DCs. Data shown are representative of at least 3 independent experiments (n = 3). Error bars represent SEM. *P < 0.05, Student’s t test.