TABLE 4.
Characteristics of patients infected or colonized with S. marcescens isolates for which MICs differed significantly over time
| Patient no. | Sexa/age (yr) of patient | Date of isolation (day-mo-yr) | Source | Wardb | MIC (μg/ml)c
|
ESBL presence | RAPD type | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PIP | TZP | CRO | CAZ | FEP | IPM | MEM | AMK | NET | GEN | CIP | |||||||
| 1 | M/65 | 15-09-97 | Tracheal aspirate | ICU (1) | 256 | 64 | 18 | 1 | 1 | 1 | 0.06 | 32 | 64 | 1 | 1 | − | B |
| 02-10-97 | Blood | 64 | 32 | 4 | 2 | 0.5 | 1 | 0.125 | 32 | 64 | 2 | 1 | − | B | |||
| 2 | F/71 | 24-11-97 | Drainage | ICU (1) | 64 | 4 | 128 | 4 | 4 | 1 | 0.03 | 32 | 64 | 1 | 1 | − | B |
| 24-11-97 | Drainage | 64 | 4 | 16 | 64 | 1 | 0.5 | 0.06 | 32 | 64 | 2 | 1 | − | I | |||
| 3 | M/40 | 31-10-97 | Tracheal aspirate | Neurosurgery (1) | 256 | 32 | 8 | 1 | 0.5 | 0.5 | 0.03 | 4 | 8 | 16 | 0.5 | − | A |
| 31-10-97 | Tracheal aspirate | 1 | 1 | 0.25 | 0.25 | 0.25 | 1 | 0.06 | 1 | 1 | 0.5 | 0.06 | − | F | |||
| 06-11-97 | Blood | 32 | 8 | 4 | 0.5 | 0.25 | 0.5 | 0.06 | 4 | 16 | 8 | 0.5 | − | A | |||
| 4 | M/17 | 06-07-98 | Urine | Nephrology (1) | 128 | 16 | 8 | 1 | 0.5 | 0.5 | 0.06 | 32 | 64 | 1 | 1 | − | B |
| 18-01-99 | Urine | 128 | 64 | 8 | 2 | 0.25 | 1 | 0.125 | 1 | 8 | 8 | 0.125 | − | B | |||
| 5 | M/53 | 07-12-98 | Urine | Internal medicine (2) | >256 | 128 | 2 | 1 | 1 | 0.5 | 0.06 | 0.5 | 8 | 64 | 0.5 | − | AA |
| 26-02-99 | Urine | >256 | 8 | >128 | 16 | >128 | 2 | 1 | >512 | >256 | >512 | 4 | +d | X | |||
| 6 | M/52 | 08-04-99 | Drainage | ICU (1) | 64 | 16 | 16 | 4 | 1 | 0.5 | 0.03 | 4 | 32 | 64 | 0.25 | − | B |
| 23-06-99 | Throat swab | General surgery (1) | >256 | 32 | 64 | 4 | 8 | 0.5 | 0.06 | >512 | >256 | >512 | +d | A | |||
| 7 | M/42 | 28-09-99 | Wound | Dermatology (1) | 128 | 8 | 2 | 1 | 0.25 | 1 | 0.06 | >512 | 8 | 4 | 0.5 | − | A |
| 03-12-99 | Wound | 256 | 8 | >128 | 4 | 32 | 0.5 | 0.125 | >512 | >256 | >512 | 0.5 | − | A | |||
| 8 | M/5 | 05-02-00 | Urine | Pediatric hematology (1) | 256 | 1 | 16 | 32 | 4 | 0.5 | 0.25 | 2 | 16 | 128 | 0.06 | +e | AR |
| 29-05-00 | Throat swab | 1.0 | 2 | 0.25 | 0.25 | 0.25 | 0.5 | 0.06 | 2 | 0.5 | 0.5 | 0.06 | − | BC | |||
| 9 | M/41 | 20-03-00 | Drainage | General surgery (1) | 64 | 32 | 16 | 1 | 0.5 | 1 | 0.06 | 16 | 16 | 2 | 0.5 | − | B |
| 31-03-00 | Drainage | 256 | 1 | >128 | 8 | 128 | 2 | 0.25 | 2 | 4 | 64 | 4 | +d | X | |||
| 10 | M/45 | 10-07-00 | Wound | Plastic surgery (1) | >256 | 4 | 0.25 | 0.25 | 0.25 | 0.25 | 0.03 | 32 | >256 | 32 | 0.5 | − | BH |
| 10-07-00 | Wound | >256 | 64 | 8 | 32 | 2 | 0.25 | 0.03 | 1 | 8 | 64 | 0.5 | − | BI | |||
| 11 | M/59 | 30-11-00 | Blood | Nephrology (1) | 128 | 32 | 64 | 4 | 16 | 1 | 0.125 | >512 | 0.5 | >512 | 2 | +d | A |
| 06-12-00 | Wound | 64 | 32 | 8 | 2 | 0.5 | 1 | 0.06 | 2 | 0.5 | 1 | 1 | − | A | |||
a
M, male; F, female.
b
(1) and (2), hospital 1 and hospital 2, respectively.
c
Abbreviations: PIP, piperacillin; TZP, piperacillin-tazobactam; CRO, ceftriaxone; CAZ, ceftazidime; FEP, cefepime; IPM, imipenem; MEM, meropenem; AMK, amikacin; NET, netilmicin; GEN, gentamicin; CIP, ciprofloxacin.
d
CTX-M-3.
e
TEM-47.