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. 2015 Apr 20;125(5):2109–2122. doi: 10.1172/JCI79134

Figure 2. Homozygous deletion of Tert delays MYC-driven lymphomagenesis in vivo.

Figure 2

(A) Kaplan-Meier curves showing the tumor-free survival of EμMYC Tert+/+, EμMYC Tert+/–, and EμMYC Tert–/– mice. (B) Kaplan-Meier curves showing the tumor-free survival of EμMYC Terc+/+, EμMYC Terc+/–, and EμMYC Terc–/– mice. (C) MYC levels in spleen B cells from 12-week-old EμMYC Tert+/+ (n = 3), EμMYC Tert+/– (n = 4), and EμMYC Tert–/– mice (n = 5). (D) wbc counts, spleen weights, and tumor weights in 12-week-old EμMYC Tert+/+, EμMYC Tert+/–, and EμMYC Tert–/– mice. Each dot represents an independent mouse. The horizontal bars represent the mean. (E) Representative immunohistochemistry images (original magnification, ×10), showing B220 and Ki67 staining in EμMYC Tert+/+, EμMYC Tert+/–, and EμMYC Tert–/– spleens. Spleens from at least 3 mice of each genotype were analyzed. One-way ANOVA with Dunnett’s multiple comparison test was used to compare differences between the various genotypes and EμMYC Tert+/+. P < 0.05, P < 0.01, P > 0.05, vs. EμMYC Tert+/+.