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. 2015 Apr 13;125(5):2059–2068. doi: 10.1172/JCI80514

Figure 6. Drugs and a mutation that extend lifespan elevate PSBM8 in mouse liver.

Figure 6

(A) Rapamycin (n = 4). (B) NDGA (n = 12). (C) EST (n = 4). (D) Snell dwarf (n = 6). Data are presented as bars showing PSMB8 levels (ab3329 purchased from Abcam) adjusted to β-actin (4970S purchased from Cell Signaling). Data are plotted as a percentage of control males. Error bars represent SEM. Controls for the 3 drugs were age- and sex-matched mice that consumed standard chow without drugs, and controls for the Snell dwarf mice were normal-sized, same-sex littermates. Statistical significance was evaluated by 2-way ANOVA, with drug (or genotype) effects and sex effects considered as independent variables.