Figure 4. CSF concentrations of mHTT and of the neuronal proteins tau and NFL are significantly associated.

Significant positive linear associations were seen between CSF concentrations of mHTT and tau in (A) London (n = 9) and (B) Vancouver (n = 30) cohorts. A strikingly close association was seen between CSF mHTT concentration and NFL concentration in the (C) London (n = 9) and (D) Vancouver (n = 20) cohorts. Data were calculated by linear regression analysis.