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Design of the artificial analogues of box C/D RNAs. Conserved elements of snoRNA analogues – boxes C (C’) and D (D’) – are colored in green. Target nucleotides in rRNA are arrowed with the number of a nucleotide denoted according to [26]. Known sites of 2’-O-methylation in 28S rRNA are colored in red. The rectangles contain the designation of box C/D RNA analogues complementary to a specific region in the corresponding rRNA
