Fig. 2.

Changes in the response kinetics in the presence of 1000 μM memantine (A) and 1000 μM 9AA (B). The gray trace shows the response in the presence of an inhibitor. The response is normalized by the amplitude to the control level. Memantine, a weak inhibitor, increases the rate of desensitization. Contrary, 9AA broadens the response. C, examples of the currents evoked by modest (red) and strong (black) acidifications. As in the presence of 9AA (B), response to modest acidification has a low amplitude and slow kinetics