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Dependence of the 9AA effect on the ASIC1b activation level. Representative examples of currents through ASIC1b are shown for different pH values in the presence and absence of 500 μM 9AA. Insets show superimposed currents at a larger scale. At pH=6.5 (lower inset), inhibition is almost complete. At more acidic pH, which causes strong ASIC activation (right inset), inhibition becomes modest
